Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557429 | 0.91 | L3MBTL1 (0.50) | L3MBTL1KMT2AALDH1A1CHEK1CYP11B1 | |
| SCHEMBL2035559 | 0.81 | CHEK1 (0.51) | L3MBTL1KDM4EHSD17B10KMT2AALDH1A1 | |
| SCHEMBL2034828 | 0.79 | KDM4E (0.55) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL6567644 | 0.79 | KMT2A (0.58) | L3MBTL1KDM4EHSD17B10KMT2AALDH1A1 | |
| SCHEMBL2037216 | 0.77 | CHEK1 (0.51) | KDM4EKMT2ACHEK1MEN1LRRK2 | |
| SCHEMBL2035648 | 0.77 | CHEK1 (0.54) | KDM4EKMT2AALDH1A1CHEK1MEN1 | |
| SCHEMBL2035402 | 0.77 | CHEK1 (0.51) | KDM4EKMT2ACHEK1MEN1LRRK2 | |
| SCHEMBL2035693 | 0.76 | BRD4 (0.53) | L3MBTL1KDM4EKMT2AALDH1A1CHEK1 | |
| SCHEMBL5163297 | 0.76 | CHEK1 (0.51) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL2034631 | 0.75 | BRD4 (0.54) | L3MBTL1ALDH1A1CHEK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608618-B2 | Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1 | ICOS CORPORATION (US) | 2009-10-27 | — | — | US | disclosed |
| US-20050245525-A1 | Compounds useful for inhibiting CHK1 | ICOS CORPORATION (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245525-A1 | Compounds useful for inhibiting CHK1 | CHEK1, PCNA, CHEK2 | L3MBTL1 310/4885KDM4E 2395/4885HSD17B10 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.