Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 4/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564978 | 0.84 | ALDH1A1 (0.53) | KDM4EALDH1A1L3MBTL1TDP1HPGD | |
| SCHEMBL7094351 | 0.71 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1HPGDMAPT | |
| SCHEMBL12130607 | 0.71 | MEN1 (0.43) | KDM4EMEN1KMT2A | |
| SCHEMBL5163007 | 0.70 | POLB (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28905014 | 0.69 | BTK (0.57) | KDM4EALDH1A1L3MBTL1TDP1HPGD | |
| SCHEMBL9283467 | 0.68 | KMT2A (0.44) | KDM4EALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL9283477 | 0.68 | CHRM4 (0.49) | ALDH1A1L3MBTL1MAPTNPSR1MEN1 | |
| SCHEMBL10650658 | 0.68 | SCN1A (0.48) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9285777 | 0.68 | CHRM4 (0.48) | ALDH1A1L3MBTL1MAPTNPSR1MEN1 | |
| SCHEMBL9285771 | 0.68 | KMT2A (0.44) | KDM4EALDH1A1HPGDMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511065-B2 | Mixed lineage kinase modulators | ELI LILLY AND COMPANY (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | ELI LILLY AND COMPANY | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | MYLK2, CSNK1G2, CSNK1A1 | KDM4E 2001/4885ALDH1A1 3779/4885L3MBTL1 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.