Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.38 |
| ▸ | PPARD | Q03181 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244425 | 0.77 | PPARA (0.49) | PPARAPTGS2PTGDR2PPARDPPARG | |
| SCHEMBL4565189 | 0.76 | SCD (0.50) | PPARAPPARDPPARGSCD | |
| SCHEMBL242780 | 0.69 | PPARA (0.52) | PPARAPTGDR2PPARDPPARGSCD | |
| SCHEMBL1909737 | 0.67 | PPARA (0.47) | PPARAPTGS2PTGDR2PPARDPPARG | |
| SCHEMBL245124 | 0.64 | SCD (0.76) | SCDNPC1LMNA | |
| SCHEMBL242868 | 0.64 | SCD (0.56) | PPARAPPARDPPARGSCDLMNA | |
| SCHEMBL244247 | 0.64 | MEN1 (0.52) | PPARAPPARDPPARGSCDNPC1 | |
| SCHEMBL12134067 | 0.64 | SCD (0.60) | PPARAPPARDSCDLMNA | |
| SCHEMBL244719 | 0.62 | SCD (0.64) | PPARAPPARDPPARGSCD | |
| SCHEMBL63779 | 0.59 | KMT2A (0.64) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |