Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 5/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706735 | 1.00 | HCRTR1 (0.33) | HCRTR1PDE10AIRAK4TTKCCNA2 | |
| SCHEMBL3700322 | 0.82 | PSEN1 (0.46) | KCNH2 | |
| SCHEMBL3701407 | 0.81 | CHEK1 (0.34) | IRAK4TTKCCNA2CDK2CHEK1 | |
| SCHEMBL3703137 | 0.81 | TTK (0.34) | PDE10AIRAK4TTKCCNA2CDK2 | |
| SCHEMBL3699631 | 0.76 | CHEK1 (0.34) | HCRTR1PDE10AIRAK4TTKCCNA2 | |
| SCHEMBL3704450 | 0.73 | TTK (0.35) | IRAK4TTKCCNA2CDK2CHEK1 | |
| SCHEMBL4565292 | 0.73 | P2RX7 (0.33) | — | |
| SCHEMBL3701673 | 0.73 | P2RX7 (0.33) | — | |
| SCHEMBL3704373 | 0.71 | IRAK4 (0.35) | HCRTR1IRAK4TTKCCNA2CDK2 | |
| SCHEMBL3706768 | 0.69 | PSEN1 (0.36) | IRAK4TTKCCNA2CDK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |