Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 9/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 7/20 | 0.47 |
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580494 | 0.81 | CDK1 (0.43) | CSNK1DCSNK1ECDK2CCNE1FLT3 | |
| SCHEMBL3585124 | 0.64 | CDK1 (0.48) | CSNK1DCSNK1ECDK2CCNE1PDGFRA | |
| SCHEMBL3592810 | 0.63 | CDK1 (0.44) | CSNK1DCSNK1EFLT3PDGFRACDK1 | |
| SCHEMBL3585775 | 0.63 | CDK1 (0.54) | CSNK1DCSNK1ECDK2CCNE1FLT3 | |
| SCHEMBL3589570 | 0.62 | CSNK1D (0.41) | CSNK1DCSNK1ECDK2CCNE1CDK1 | |
| SCHEMBL27148924 | 0.61 | CYP2D6 (0.56) | CSNK1DCSNK1ECDK2CCNE1CCNE2 | |
| SCHEMBL17352531 | 0.61 | CCNE1 (0.85) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3595696 | 0.61 | CDK1 (0.59) | CDK2CCNE1FLT3PDGFRACDK1 | |
| SCHEMBL5195166 | 0.60 | CDK2 (0.74) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL5195168 | 0.60 | CDK2 (0.74) | CDK2CCNE1CCNE2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | claimed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | claimed |