Sugi Predict

Sugi Predict / Compounds / SCHEMBL4565794

SCHEMBL4565794

SCHEMBL4565794

Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1-c1cc(C(=O)NCC(C)(C)C)on1

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 6/20 0.60
▸ BRAF P15056 13/20 0.57
▸ RAF1 P04049 12/20 0.57
▸ LYN P07948 2/20 0.57
▸ KIT P10721 1/20 0.51
▸ TEK Q02763 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4417023 0.95 RAF1 (0.56) CSF1RBRAFRAF1LYN
SCHEMBL4412866 0.94 RAF1 (0.56) CSF1RBRAFRAF1LYN
SCHEMBL4552241 0.94 RAF1 (0.63) CSF1RBRAFRAF1
SCHEMBL4409914 0.91 RAF1 (0.51) CSF1RBRAFRAF1LYNTEK
SCHEMBL4566542 0.89 RAF1 (0.48) BRAFRAF1
SCHEMBL5604230 0.86 RAF1 (0.59) CSF1RBRAFRAF1LYN
SCHEMBL5593431 0.85 RAF1 (0.49) CSF1RBRAFRAF1
SCHEMBL4565118 0.85 RAF1 (0.56) CSF1RBRAFRAF1
SCHEMBL4410286 0.85 RAF1 (0.49) CSF1RBRAFRAF1
SCHEMBL14473010 0.84 RAF1 (0.45) CSF1RBRAFRAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035005-A2 THERAPY USING CYTOKINE INHIBITORS Kemia, INC. (US) 2009-03-18 — — EP disclosed
WO-2007146712-A2 THERAPY USING CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-12-21 — — WO disclosed
WO-2007075896-A2 HETEROCYCLIC CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-07-05 — — WO disclosed