Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.48 |
| ▸ | FLT3 | P36888 | 6/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590820 | 0.87 | PDGFRA (0.58) | CDK2PDGFRAFLT3SRCCCNE1 | |
| SCHEMBL12727080 | 0.87 | PDGFRA (0.58) | CDK2PDGFRAFLT3SRCCCNE1 | |
| SCHEMBL4372361 | 0.86 | CDK2 (0.67) | CDK2PDGFRAFLT3SRCCCNE1 | |
| SCHEMBL4372360 | 0.86 | CDK2 (0.67) | CDK2PDGFRAFLT3SRCCCNE1 | |
| Hydrochloric Acid SCHEMBL4370787 | 0.85 | CDK2 (0.66) | CDK2PDGFRAFLT3SRCCCNE1 | |
| Hydrochloric Acid SCHEMBL4370784 | 0.85 | CDK2 (0.66) | CDK2PDGFRAFLT3SRCCCNE1 | |
| SCHEMBL6015440 | 0.84 | YTHDC1 (0.52) | — | |
| SCHEMBL4374504 | 0.79 | CDK2 (0.64) | CDK2PDGFRAFLT3SRCCCNE1 | |
| SCHEMBL4374509 | 0.79 | CDK2 (0.64) | CDK2PDGFRAFLT3SRCCCNE1 | |
| SCHEMBL4372817 | 0.78 | FLT3 (0.68) | CDK2PDGFRAFLT3SRCCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | disclosed |