Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.65 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565856 | 0.87 | MAPK10 (0.65) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| SCHEMBL1232326 | 0.82 | MAPK10 (0.83) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| SCHEMBL15160609 | 0.81 | MAPK10 (0.65) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| SCHEMBL12901048 | 0.81 | MAPK10 (0.71) | MAPK10MAPK9PTK2ULK1EGFR | |
| SCHEMBL47302 | 0.80 | MAPK10 (0.84) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| Vs-4718 SCHEMBL29478885 | 0.79 | MAPK10 (1.00) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| Vs-4718 SCHEMBL47360 | 0.79 | MAPK10 (1.00) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| Vs-4718 SCHEMBL29381276 | 0.79 | MAPK10 (1.00) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| Vs-4718 SCHEMBL29493098 | 0.79 | MAPK10 (1.00) | MAPK10MAPK9PTK2ULK1MAPK8 | |
| SCHEMBL1230824 | 0.79 | MAPK10 (0.78) | MAPK10MAPK9PTK2ULK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134689-A2 | INHIBITORS OF FOCAL ADHESION KINASE | The Scripps Research Institute (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008115369-A2 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-25 | — | — | WO | disclosed |