Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 11/20 | 0.84 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.84 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.84 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232326 | 0.93 | MAPK10 (0.83) | MAPK10MAPK9PTK2ZAP70MAPK1 | |
| SCHEMBL12887672 | 0.92 | MAPK10 (0.72) | MAPK10MAPK9PTK2MAPK1MAPK3 | |
| Vs-4718 SCHEMBL47360 | 0.92 | MAPK10 (1.00) | MAPK10MAPK9PTK2MAPK1FGFR1 | |
| Vs-4718 SCHEMBL29381276 | 0.92 | MAPK10 (1.00) | MAPK10MAPK9PTK2MAPK1FGFR1 | |
| Vs-4718 SCHEMBL29493098 | 0.92 | MAPK10 (1.00) | MAPK10MAPK9PTK2MAPK1FGFR1 | |
| Vs-4718 SCHEMBL29478885 | 0.92 | MAPK10 (1.00) | MAPK10MAPK9PTK2MAPK1FGFR1 | |
| Vs-4718 SCHEMBL30354503 | 0.91 | PTK2 (1.00) | MAPK10MAPK9PTK2MAPK1FGFR1 | |
| SCHEMBL12901048 | 0.90 | MAPK10 (0.71) | MAPK10MAPK9PTK2FGFR1EGFR | |
| SCHEMBL12887696 | 0.86 | MAPK10 (0.72) | MAPK10MAPK9PTK2ZAP70MAPK1 | |
| SCHEMBL1231883 | 0.85 | MAPK10 (0.81) | MAPK10MAPK9PTK2MAPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11564927-B2 | Therapeutic compositions, combinations, and methods of use | VERASTEM, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| US-20210030703-A1 | USE OF CALORIC RESTRICTION MIMETICS FOR POTENTIATING CHEMO-IMMUNOTHERAPY FOR THE TREATMENT OF CANCERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-02-04 | — | — | US | disclosed |
| US-20200330471-A1 | THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE | RGCM SA LLC, AS PURCHASER AGENT | 2020-10-22 | — | — | US | disclosed |
| US-20180177788-A1 | THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE | RGCM SA LLC, AS PURCHASER AGENT | 2018-06-28 | — | — | US | disclosed |
| US-9580439-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580439-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580439-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-02-28 | — | — | US | disclosed |
| WO-2017004192-A1 | THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE | VERASTEM, INC. (US) | 2017-01-05 | — | — | WO | disclosed |
| US-9505719-B2 | Synthesis and use of kinase inhibitors | VERASTEM, INC. (US) | 2016-11-29 | — | — | US | disclosed |
| WO-2016109426-A1 | ORAL DOSING REGIMEN OF A DUAL MTOR AND PI3 INHIBITOR | VERASTEM, INC. (US) | 2016-07-07 | — | — | WO | disclosed |
| US-20130281443-A1 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-10-24 | — | — | US | disclosed |
| US-8501763-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501763-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501763-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-06 | — | — | US | disclosed |
| WO-2012012139-A1 | SYNTHESIS AND USE OF KINASE INHIBITORS | PONIARD PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012006081-A1 | ORAL FORMULATION OF KINASE INHIBITORS | PONIARD PHARMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |
| US-20110046121-A1 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046121-A1 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046121-A1 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-24 | — | — | US | disclosed |
| WO-2008115369-A2 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046121-A1 | INHIBITORS OF FOCAL ADHESION KINASE | PTK2, CABLES1, TNK2 | MAPK10 590/4885MAPK9 239/4885PTK2 1/4885 |
| US-11564927-B2 | Therapeutic compositions, combinations, and methods of use | PTK2, CD274, PDCD1LG2 | MAPK10 804/4885MAPK9 1136/4885PTK2 1/4885 |
| US-20210030703-A1 | USE OF CALORIC RESTRICTION MIMETICS FOR POTENTIATING CHEMO-IMMUNOTHERAPY FOR THE TREATMENT OF CANCERS | CD274, PDCD1, PDCD10 | MAPK10 1805/4885MAPK9 3263/4885PTK2 4571/4885 |
| US-20200330471-A1 | THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE | PTK2, CD274, PDCD1LG2 | MAPK10 804/4885MAPK9 1136/4885PTK2 1/4885 |
| US-20130281443-A1 | INHIBITORS OF FOCAL ADHESION KINASE | PTK2, CABLES1, TNK2 | MAPK10 590/4885MAPK9 239/4885PTK2 1/4885 |
| US-20180177788-A1 | THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE | PTK2, CD274, PDCD1LG2 | MAPK10 804/4885MAPK9 1136/4885PTK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.