Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 11/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982900 | 0.88 | KCNN4 (0.39) | KCNN4LRRK2METMAPK1 | |
| SCHEMBL986036 | 0.88 | MAPK1 (0.48) | KCNN4METMAPK1 | |
| SCHEMBL985945 | 0.86 | KDR (0.40) | KCNN4LRRK2METMAPK1 | |
| SCHEMBL985718 | 0.86 | LRRK2 (0.48) | KCNN4LRRK2METMAPK1 | |
| SCHEMBL988541 | 0.85 | ALOX5AP (0.43) | KCNN4LRRK2METMAPK1 | |
| SCHEMBL14399170 | 0.85 | LRRK2 (0.38) | KCNN4LRRK2METMAPK1 | |
| SCHEMBL982775 | 0.84 | IKBKE (0.42) | KCNN4LRRK2MAPK1 | |
| SCHEMBL4404579 | 0.84 | MAPK1 (0.40) | KCNN4METMAPK1 | |
| SCHEMBL988133 | 0.84 | MAPK1 (0.40) | KCNN4LRRK2METMAPK1 | |
| SCHEMBL984960 | 0.83 | MET (0.41) | KCNN4LRRK2METMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |