Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25859374 | 0.85 | HDAC1 (0.50) | HDAC1LMNAPOLBKDM4AMALT1 | |
| SCHEMBL29655427 | 0.83 | MALT1 (0.54) | HDAC1LMNAPOLBKDM4AMALT1 | |
| SCHEMBL2975056 | 0.83 | MALT1 (0.54) | HDAC1LMNAPOLBKDM4AMALT1 | |
| SCHEMBL3993854 | 0.83 | HDAC1 (0.41) | HDAC1LMNA | |
| SCHEMBL22605515 | 0.81 | BRD4 (0.49) | HDAC1MALT1BCHEBRD4DRD2 | |
| SCHEMBL23997305 | 0.80 | HDAC1 (0.63) | HDAC1KDM4ANAMPT | |
| SCHEMBL30336954 | 0.80 | HDAC1 (0.63) | HDAC1KDM4ANAMPT | |
| SCHEMBL22121240 | 0.80 | HDAC1 (0.49) | HDAC1LMNAPOLBKDM4AMALT1 | |
| SCHEMBL28514702 | 0.79 | IDO1 (0.47) | HDAC1LMNAMALT1BCHEIDO1 | |
| SCHEMBL21071330 | 0.78 | ADORA2A (0.47) | HDAC1LMNAPOLBMALT1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778231-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1778231-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020415-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |