Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442417 | 0.86 | PIM2 (0.44) | AAK1PIM2PIM1PIM3 | |
| SCHEMBL4445771 | 0.81 | AAK1 (0.39) | MAPKAPK2AAK1ACVR1BTGFBR1ACVRL1 | |
| SCHEMBL4555787 | 0.80 | TGFBR1 (0.36) | MAPKAPK2AAK1ACVR1BTGFBR1ACVRL1 | |
| SCHEMBL4433849 | 0.79 | IRAK4 (0.40) | ACVR1BTGFBR1ACVRL1NAMPTPIM2 | |
| SCHEMBL4444149 | 0.75 | PIM2 (0.44) | PIM2PIM1PIM3 | |
| SCHEMBL4434968 | 0.74 | AKT1 (0.39) | ACVR1BTGFBR1ACVRL1NAMPTGPBAR1 | |
| SCHEMBL27796427 | 0.72 | AAK1 (0.36) | AAK1ACVR1BTGFBR1ACVRL1LATS1 | |
| SCHEMBL4445160 | 0.69 | PIK3CA (0.39) | MAPKAPK2AAK1ACVR1BTGFBR1ACVRL1 | |
| SCHEMBL4437161 | 0.68 | PIM2 (0.44) | PIM2PIM1PIM3 | |
| SCHEMBL4439485 | 0.68 | MAP4K1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |