Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | S100B | P04271 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555529 | 0.92 | LGMN (0.50) | LGMNMAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11907247 | 0.82 | MAPT (0.58) | MAPTKEAP1PIM1PIM3PIM2 | |
| SCHEMBL1710364 | 0.82 | MAPT (0.58) | MAPTKEAP1PIM1PIM3PIM2 | |
| SCHEMBL11907530 | 0.82 | MAPT (0.58) | MAPTKEAP1PIM1PIM3PIM2 | |
| Hydrochloric Acid SCHEMBL30050796 | 0.80 | MAPT (0.56) | MAPTKEAP1PIM1PIM3PIM2 | |
| SCHEMBL9425930 | 0.80 | MAPT (0.59) | MAPTKEAP1PIM1PIM3PIM2 | |
| SCHEMBL30309957 | 0.80 | MAPT (0.59) | MAPTKEAP1PIM1PIM3PIM2 | |
| SCHEMBL15783989 | 0.77 | CYP11B1 (0.54) | LGMNMAPTPIM2ALDH1A1 | |
| SCHEMBL11907690 | 0.74 | MAPT (0.50) | LGMNMAPTKEAP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15783934 | 0.73 | MAPT (0.56) | MAPTALDH1A1GAAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |