Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.58 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063301 | 0.83 | S1PR1 (0.58) | S1PR1S1PR3FFAR1MAOB | |
| SCHEMBL606466 | 0.78 | TSHR (0.55) | TSHR | |
| Hydrochloric Acid SCHEMBL3494457 | 0.77 | TSHR (0.57) | TSHR | |
| SCHEMBL1602267 | 0.74 | S1PR1 (0.81) | S1PR1S1PR3FFAR1KCNH2MAOB | |
| SCHEMBL1603237 | 0.73 | S1PR1 (1.00) | S1PR1S1PR3KCNH2 | |
| Alcohol SCHEMBL27541427 | 0.73 | TSHR (0.53) | TSHRF10 | |
| SCHEMBL28687641 | 0.73 | TSHR (0.53) | TSHRF10 | |
| SCHEMBL1601401 | 0.73 | S1PR1 (0.52) | S1PR1S1PR3FFAR1KCNH2MAOB | |
| SCHEMBL1602885 | 0.71 | S1PR1 (0.58) | S1PR1S1PR3FFAR1KCNH2MAOB | |
| SCHEMBL3699394 | 0.71 | MAOB (0.63) | S1PR1S1PR3FFAR1KCNH2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1965807-A2 | S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF | Epix Delaware, Inc. (US) | 2008-09-10 | — | — | EP | claimed |
| WO-2007061458-A2 | S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF | EPIX DELAWARE, INC. (US) | 2007-05-31 | — | — | WO | claimed |
| EP-2364976-B1 | S1P receptor modulating compounds and use thereof | EPIX PHARM INC (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-2121648-A2 | S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF | EPIX Pharmaceuticals, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2007109334-A2 | SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF | EPIX DELAWARE, INC. (US) | 2007-09-27 | — | — | WO | disclosed |