Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LGMN | Q99538 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093746 | 0.82 | LMNA (0.71) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL23342230 | 0.80 | MAPT (0.47) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL13221731 | 0.79 | LMNA (0.52) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL150647 | 0.79 | LMNA (0.52) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14386403 | 0.79 | LMNA (0.52) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14866602 | 0.79 | MAPT (0.55) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18406000 | 0.79 | MAPT (0.55) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17278983 | 0.78 | GSK3B (0.51) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17133379 | 0.76 | MAPT (0.48) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4342274 | 0.76 | LMNA (0.64) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021316-A1 | INHIBITORS OF POLO-LIKE KINASES | Abbott Laboratories (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007140233-A1 | INHIBITORS OF POLO-LIKE KINASES | ABBOTT LABORATORIES (US) | 2007-12-06 | — | — | WO | disclosed |