Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993437 | 0.93 | HTR6 (0.49) | HTR6BCHEDRD2HTR1AHTR2A | |
| SCHEMBL2000732 | 0.86 | HTR6 (0.46) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| SCHEMBL1997431 | 0.82 | HTR6 (0.46) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| Trifluoroacetic Acid SCHEMBL1997492 | 0.80 | HTR6 (0.43) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| SCHEMBL1995749 | 0.79 | HTR6 (0.46) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| Trifluoroacetic Acid SCHEMBL1997458 | 0.77 | HTR6 (0.47) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| SCHEMBL1998144 | 0.77 | HTR6 (0.45) | HTR6BCHE | |
| SCHEMBL1995846 | 0.76 | HTR6 (0.54) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| SCHEMBL1994506 | 0.74 | HTR6 (0.46) | HTR6BCHEDRD2HTR1AHTR2A | |
| Trifluoroacetic Acid SCHEMBL1997574 | 0.73 | HTR6 (0.40) | HTR6CYP3A4CYP2D6DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091953-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4]OXAZEPINO [6, 7-E]INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (publ) (SE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |