Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | SYK | P43405 | 7/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.48 |
| ▸ | PAK4 | O96013 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.48 |
| ▸ | STK3 | Q13188 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3894734 | 0.81 | KDR (0.69) | KDRSYKDAPK3PRKD3MAP4K4 | |
| SCHEMBL4435114 | 0.78 | KDR (0.65) | KDRSYKDAPK3PRKD3MAP4K4 | |
| Hydrochloric Acid SCHEMBL6246305 | 0.78 | KDR (0.64) | KDRSYKDAPK3PRKD3MAP4K4 | |
| SCHEMBL13867865 | 0.77 | KDR (0.72) | KDRSYKMAP4K4FLT3CLK2 | |
| SCHEMBL13867837 | 0.77 | KDR (0.80) | KDRSYKDAPK3PRKD3MAP4K4 | |
| SCHEMBL3892583 | 0.76 | KDR (0.69) | KDRSYKDAPK3PRKD3MAP4K4 | |
| SCHEMBL13867809 | 0.75 | KDR (0.66) | KDRRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL13867819 | 0.75 | KDR (0.68) | KDRSYKDAPK3PRKD3MAP4K4 | |
| SCHEMBL3890896 | 0.74 | KDR (1.00) | KDRSYKDAPK3PRKD3MAP4K4 | |
| SCHEMBL13867815 | 0.73 | KDR (0.66) | KDRSYKDAPK3PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4392348-B2 | — | — | 2009-12-24 | — | — | JP | claimed |
| JP-2006502118-A | — | — | 2006-01-19 | — | — | JP | claimed |
| EP-1562933-A2 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS | Amgen Inc. (US) | 2005-08-17 | — | — | EP | claimed |
| WO-2004007481-A2 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATES DISORDERS | AMGEN INC. (US) | 2004-01-22 | — | — | WO | claimed |