Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 11/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304207 | 0.84 | BACE1 (0.41) | PDE4APDE4BPDE4CPDE4DPROKR1 | |
| SCHEMBL4315738 | 0.82 | PDE4D (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4312390 | 0.75 | KMO (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4305817 | 0.74 | PDE4D (0.36) | EZH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4306393 | 0.74 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4308458 | 0.73 | PDE4D (0.37) | EZH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28872052 | 0.73 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4306019 | 0.72 | PDE4D (0.37) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL4313892 | 0.72 | PDE4D (0.39) | PDE4APDE4BPDE4CPDE4DCES2 | |
| SCHEMBL4571219 | 0.72 | PDE4B (0.35) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137161-A1 | AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115552-A1 | AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | disclosed |