Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174159 | 0.84 | PDGFRA (0.59) | METKDRAXLPDGFRA | |
| SCHEMBL29487188 | 0.84 | PDGFRA (0.59) | METKDRAXLPDGFRA | |
| SCHEMBL453053 | 0.83 | MET (0.53) | METKDRAXLPDGFRAFLT3 | |
| SCHEMBL22009936 | 0.81 | PDGFRA (0.56) | METKDRAXLPDGFRAFLT3 | |
| SCHEMBL1133098 | 0.80 | AXL (0.59) | METKDRAXLPDGFRAMERTK | |
| SCHEMBL1133096 | 0.80 | AXL (0.59) | METKDRAXLPDGFRAMERTK | |
| SCHEMBL456691 | 0.79 | MET (0.52) | METKDRAXLPDGFRAFLT3 | |
| SCHEMBL371890 | 0.79 | MET (0.46) | METKDRAXLPDGFRAFLT3 | |
| SCHEMBL13936618 | 0.78 | PDGFRA (0.52) | METKDRAXLPDGFRAFLT3 | |
| SCHEMBL30697769 | 0.78 | PDGFRA (0.52) | METKDRAXLPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621904-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | Advenchen Laboratories, LLC (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |