Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.58 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052826 | 0.96 | KDM5A (0.55) | KDM5AKDM7AESR1PGRCHRM2 | |
| SCHEMBL2414209 | 0.96 | KDM5A (0.55) | KDM5AKDM7AESR1PGRCHRM2 | |
| SCHEMBL9486201 | 0.95 | ESR1 (0.56) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL9486770 | 0.95 | ESR1 (0.56) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL9487404 | 0.94 | ESR1 (0.55) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL30140813 | 0.94 | ESR1 (0.68) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL283110 | 0.94 | ESR1 (0.68) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL2332776 | 0.94 | SIRT3 (0.56) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL16361325 | 0.94 | SIRT3 (0.54) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL15426051 | 0.94 | ESR1 (0.58) | ESR1PGRCHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889734-B2 | Process for the preparation of dronedarone | SANOFI (FR) | 2014-11-18 | — | — | US | disclosed |
| US-20140206761-A1 | PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS | CAMBREX KARLSKOGA AB (SE) | 2014-07-24 | — | — | US | disclosed |
| US-8779201-B2 | Process for preparing benzofurans | CAMBREX KARLSKOGA AB (SE) | 2014-07-15 | — | — | US | disclosed |
| US-20130261321-A1 | PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2013-10-03 | — | — | US | disclosed |
| US-8519165-B2 | Process for preparing benzofurans | CAMBREX KARLSKOGA AB (SE) | 2013-08-27 | — | — | US | disclosed |
| US-8501971-B2 | Process for the preparation of dronedarone | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-20120289717-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2012-11-15 | — | — | US | disclosed |
| US-20120122971-A1 | NEW PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS | CAMBREX KARLSKOGA AB (SE) | 2012-05-17 | — | — | US | disclosed |
| US-20120046356-A1 | NEW PROCESS FOR PREPARING DIKETONES AND MEDICAMENTS | CAMBREX KARLSKOGA AB (SE) | 2012-02-23 | — | — | US | disclosed |
| US-20100292319-A1 | PROCESS FOR PREPARING BENZOFURANS | CAMBREX KARLSKOGA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289717-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | CYP3A4, CYP4B1, CYP2D6 | KDM5A 1800/4885KDM7A 2370/4885ESR1 4507/4885 |
| US-20130261321-A1 | PROCESS FOR THE PREPARATION OF DRONEDARONE | CYP2D6, CYP3A4, CYP4B1 | KDM5A 1538/4885KDM7A 2252/4885ESR1 4472/4885 |
| US-20140206761-A1 | PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS | CYP3A4, CYP1A2, CYP2D6 | KDM5A 1868/4885KDM7A 2121/4885ESR1 3445/4885 |
| US-20120046356-A1 | NEW PROCESS FOR PREPARING DIKETONES AND MEDICAMENTS | CYP3A4, DHPS, CYP2D6 | KDM5A 1267/4885KDM7A 1211/4885ESR1 4712/4885 |
| US-20120122971-A1 | NEW PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS | CYP3A4, CYP1A2, CYP4B1 | KDM5A 1871/4885KDM7A 2076/4885ESR1 3068/4885 |
| US-20100292319-A1 | PROCESS FOR PREPARING BENZOFURANS | CYP2F1, CYP3A4, CYP4F3 | KDM5A 2157/4885KDM7A 2206/4885ESR1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.