Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SCN2B | O60939 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37938 | 0.84 | PDE5A (0.77) | PDE5APOLBKDM4ERECQLPDE9A | |
| SCHEMBL38105 | 0.84 | PDE5A (1.00) | PDE5ACSNK2A2CSNK2BCSNK2A1POLB | |
| SCHEMBL37738 | 0.76 | PDE5A (0.56) | PDE5AKDM4EPDE9APDE1APDE1B | |
| SCHEMBL401291 | 0.76 | PDE5A (0.85) | PDE5ACSNK2A2CSNK2BPOLBKDM4E | |
| SCHEMBL17888986 | 0.75 | PDE5A (0.72) | PDE5APOLBKDM4ERECQLPDE9A | |
| SCHEMBL400846 | 0.74 | PDE5A (0.82) | PDE5ACSNK2A2CSNK2BCSNK2A1POLB | |
| SCHEMBL402247 | 0.74 | PDE5A (0.78) | PDE5ACSNK2A2CSNK2BCSNK2A1POLB | |
| SCHEMBL405547 | 0.74 | PDE5A (0.81) | PDE5ACSNK2A2CSNK2BPOLBKDM4E | |
| SCHEMBL403481 | 0.73 | PDE5A (0.76) | PDE5ACSNK2A1POLBKDM4ERECQL | |
| SCHEMBL403178 | 0.73 | PDE5A (0.78) | PDE5ACSNK2A2CSNK2BCSNK2A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |