Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46037 | 0.88 | MAPT (0.50) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL3492352 | 0.85 | PDE5A (0.69) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL38098 | 0.85 | PDE5A (0.56) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL37776 | 0.84 | PDE5A (0.61) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL3492211 | 0.84 | PDE5A (0.67) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL3492213 | 0.83 | PDE5A (0.60) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL4518642 | 0.82 | PIP4K2A (0.66) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL37886 | 0.78 | PDE5A (0.59) | PDE5AKMT2AALDH1A1KDM4ECCNE2 | |
| SCHEMBL16175769 | 0.77 | PDE5A (0.63) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL45674 | 0.76 | PDE5A (0.71) | PDE5AKMT2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |