Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456754 | 0.77 | GRIN2B (0.47) | FFAR4GRIN2BKDM5AKDM4CMAP4K4 | |
| SCHEMBL411079 | 0.76 | CNR1 (0.53) | FFAR4ALOX5APFEN1 | |
| SCHEMBL15968953 | 0.66 | FFAR4 (0.48) | FFAR4KDM4C | |
| SCHEMBL927683 | 0.66 | PARP10 (0.68) | FFAR4KDM5AKDM4C | |
| SCHEMBL7900565 | 0.65 | RARB (0.46) | FFAR4SLC22A12BRS3 | |
| SCHEMBL9060365 | 0.65 | SYK (0.41) | BRS3CHRM3 | |
| SCHEMBL16982906 | 0.64 | FEN1 (0.38) | FFAR4KDM1AALOX5APFEN1 | |
| SCHEMBL15968525 | 0.64 | SCN9A (0.48) | — | |
| SCHEMBL31149603 | 0.64 | BRS3 (0.41) | FFAR4GRIN2BKDM5ABRS3KMO | |
| SCHEMBL2704405 | 0.64 | CNR1 (0.66) | FFAR4KDM5AKDM4CXDHMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613785-A1 | HETEROARYLMETHYL AMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032018-A1 | HETEROARYLMETHYL AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |