Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411079 | 0.80 | CNR1 (0.53) | FFAR4CNR1 | |
| SCHEMBL456755 | 0.77 | FFAR4 (0.45) | GRIN2BFFAR4MAP4K4KDM5AKDM4C | |
| SCHEMBL15968176 | 0.71 | CNR1 (0.43) | FFAR4MAP4K4KDM4CCNR1 | |
| SCHEMBL30963255 | 0.71 | RIPK1 (0.48) | FFAR4SYKFFAR1PPARD | |
| SCHEMBL11472242 | 0.71 | RHEB (0.46) | KDM4CCNR1 | |
| SCHEMBL30963254 | 0.70 | SYK (0.44) | SYKFFAR1PPARD | |
| SCHEMBL2702331 | 0.70 | CNR2 (0.53) | FFAR4CNR1 | |
| SCHEMBL2704405 | 0.70 | CNR1 (0.66) | FFAR4MAP4K4KDM5AKDM4CCNR1 | |
| SCHEMBL927683 | 0.70 | PARP10 (0.68) | FFAR4KDM5AKDM4CPARP10PARP15 | |
| SCHEMBL22247444 | 0.68 | PPARD (0.57) | FFAR4KDM5AKDM4CFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613785-A1 | HETEROARYLMETHYL AMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032018-A1 | HETEROARYLMETHYL AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |