Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.51 |
| ▸ | MERTK | Q12866 | 2/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4568602 | 0.92 | MERTK (0.54) | ABCG2MERTKACP1MAPTKMT2A | |
| SCHEMBL4568601 | 0.89 | MAPT (0.59) | MERTKACP1MAPTKMT2AALDH1A1 | |
| SCHEMBL4568604 | 0.89 | NPY5R (0.52) | ABCG2MERTKACP1MAPTKMT2A | |
| SCHEMBL4568611 | 0.81 | MAPT (0.50) | ABCG2MERTKACP1MAPTKMT2A | |
| SCHEMBL4568599 | 0.81 | MERTK (0.50) | ABCG2MERTKACP1MAPTKMT2A | |
| SCHEMBL4568615 | 0.81 | MERTK (0.50) | ABCG2MERTKACP1MAPTKMT2A | |
| SCHEMBL4568605 | 0.80 | ABCG2 (0.56) | ABCG2MERTKACP1MAPTKMT2A | |
| SCHEMBL8898863 | 0.74 | NPY5R (0.74) | ABCG2MERTKMAPTKMT2AALDH1A1 | |
| SCHEMBL7420353 | 0.74 | SMN1; SMN2 (0.64) | ABCG2MERTKACP1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL8890746 | 0.74 | NPY5R (0.77) | ABCG2MERTKACP1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809343-B2 | Pyrimidine derivative, preparation method and use thereof | FUDAN UNIVERSITY (CN) | 2014-08-19 | — | — | US | disclosed |
| US-8809343-B2 | Pyrimidine derivative, preparation method and use thereof | FUDAN UNIVERSITY (CN) | 2014-08-19 | — | — | US | disclosed |
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2012-05-17 | — | — | US | disclosed |
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | DPYD, TYMP, TYMS | ABCG2 136/4885MERTK 3234/4885ACP1 4155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.