Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.68 |
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 2/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24392693 | 0.88 | HPGDS (0.70) | HDAC1HDAC2HDAC3NAMPTHPGDS | |
| SCHEMBL2230677 | 0.85 | MGAM (0.67) | HDAC1HDAC2HDAC3HDAC6HPGDS | |
| SCHEMBL3918321 | 0.84 | HDAC1 (0.66) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL3918320 | 0.84 | HDAC1 (0.66) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL21369315 | 0.84 | HDAC6 (0.72) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL28918516 | 0.83 | HDAC3 (1.00) | HDAC1HDAC2HDAC3 | |
| SCHEMBL19616809 | 0.82 | HDAC6 (1.00) | HDAC6 | |
| SCHEMBL10207296 | 0.81 | HDAC6 (1.00) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL447481 | 0.81 | NPC1 (0.54) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL7318651 | 0.78 | CAPN1 (0.57) | HDAC1HDAC2HDAC3HDAC6NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH | 2012-05-17 | — | — | US | disclosed |
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH | 2012-05-17 | — | — | US | disclosed |
| WO-2011006040-A2 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | PKD2, PKD1, HDAC4 | HDAC1 7/4885HDAC2 8/4885HDAC3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.