Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890863 | 0.86 | KDM4E (0.70) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL23499977 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL226196 | 0.83 | HSD17B10 (0.76) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL27925834 | 0.80 | KDM4E (0.66) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL4019720 | 0.80 | HSD17B10 (0.70) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL7562958 | 0.79 | F12 (0.45) | — | |
| SCHEMBL21157258 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL30873471 | 0.78 | HSD17B10 (0.68) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL4313850 | 0.78 | HSD17B10 (0.68) | KDM4EALDH1A1GAAMAPTTAAR1 | |
| SCHEMBL8398635 | 0.78 | HSD17B10 (0.68) | KDM4EALDH1A1GAAMAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH | 2012-05-17 | — | — | US | disclosed |
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH | 2012-05-17 | — | — | US | disclosed |
| WO-2011006040-A2 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | PKD2, PKD1, HDAC4 | KDM4E 852/4885ALDH1A1 1530/4885GAA 293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.