Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751674 | 0.88 | HSD17B10 (0.43) | PIK3CAPIK3CBPIK3CGPIK3CDAR | |
| SCHEMBL3769513 | 0.81 | GABRG2 (0.50) | PIK3CAPIK3CBPIK3CGPIK3CDAR | |
| SCHEMBL3759549 | 0.81 | PRKDC (0.44) | PIK3CAPIK3CBPIK3CGPIK3CDAR | |
| SCHEMBL3754789 | 0.75 | LRRK2 (0.42) | PIK3CAPRKDCALDH1A1MTORLMNA | |
| SCHEMBL3765770 | 0.74 | AOC3 (0.37) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3764986 | 0.74 | PIK3CD (0.49) | PIK3CAPIK3CBPIK3CGPIK3CDPRKDC | |
| SCHEMBL3765735 | 0.74 | PIK3CD (0.49) | PIK3CAPIK3CBPIK3CGPIK3CDPRKDC | |
| SCHEMBL3759120 | 0.73 | PARP1 (0.39) | PIK3CAMTORKDM4EROCK2 | |
| SCHEMBL3766049 | 0.71 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGPIK3CDALDH1A1 | |
| SCHEMBL3757639 | 0.71 | PIK3CD (0.41) | PIK3CAPIK3CBPIK3CGPIK3CDPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-A1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007141504-A1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2007-12-13 | — | — | WO | disclosed |