Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 11/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.39 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30433061 | 0.83 | HSD17B10 (0.49) | DYRK1AHTR6HTR2AHTR2CCCNT1 | |
| SCHEMBL21294169 | 0.83 | ELANE (0.41) | DYRK1AHTR6HTR2AHTR2CHTR7 | |
| SCHEMBL12146931 | 0.83 | ELANE (0.39) | DYRK1AHTR6HTR2AHTR2CHTR7 | |
| SCHEMBL13044512 | 0.81 | DYRK1A (0.47) | DYRK1AHTR6CCNT1PIM1CCNA2 | |
| SCHEMBL13168783 | 0.81 | CCNT1 (0.47) | DYRK1AHTR6CCNT1PIM1CCNA2 | |
| SCHEMBL4569765 | 0.80 | DYRK1A (0.46) | DYRK1AHTR6CCNT1PIM1CCNA2 | |
| SCHEMBL1093706 | 0.79 | DYRK1A (0.41) | DYRK1AHTR6HTR2AHTR2CCCNT1 | |
| SCHEMBL411033 | 0.78 | ELANE (0.36) | DYRK1AHTR6HTR2AHTR2CHTR7 | |
| SCHEMBL1092197 | 0.77 | DYRK1A (0.43) | DYRK1AHTR6CCNT1PIM1CCNA2 | |
| SCHEMBL14678667 | 0.77 | DYRK1A (0.43) | DYRK1AHTR6HTR2AHTR2CCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648086-B2 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors | ASCEPION PHARMACEUTICALS, INC. (CN) | 2014-02-11 | — | — | US | disclosed |
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | JIANG, SHAN | 2012-05-17 | — | — | US | disclosed |
| US-7947708-B2 | Compounds modulating C-kit activity | PLEXXIKON, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090105297-A1 | Compounds Modulating C-Kit Activity | PLEXXIKON INC | 2009-04-23 | — | — | US | disclosed |
| US-7498342-B2 | Compounds modulating c-kit activity | PLEXXIKON, INC. (US) | 2009-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | FLT3, CSF1R, EPHA2 | DYRK1A 654/4885HTR6 1381/4885HTR2A 1776/4885 |
| US-20090105297-A1 | Compounds Modulating C-Kit Activity | KIT, CDC7, CDK7 | DYRK1A 1356/4885HTR6 389/4885HTR2A 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.