Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168783 | 0.86 | CCNT1 (0.47) | DYRK1AKDM4ECCNT1PIM1CCNA2 | |
| SCHEMBL4569765 | 0.84 | DYRK1A (0.46) | DYRK1AKDM4EL3MBTL1CCNT1PIM1 | |
| SCHEMBL967806 | 0.81 | HTR2A (0.57) | DYRK1AKDM4ECCNT1PIM1CCNA2 | |
| SCHEMBL14678667 | 0.81 | DYRK1A (0.43) | DYRK1AKDM4ECCNT1PIM1CCNA2 | |
| SCHEMBL4569767 | 0.81 | DYRK1A (0.50) | DYRK1AKDM4ESMN1; SMN2CCNT1PIM1 | |
| SCHEMBL1092197 | 0.81 | DYRK1A (0.43) | DYRK1AKDM4ECCNT1PIM1CCNA2 | |
| SCHEMBL30433061 | 0.81 | HSD17B10 (0.49) | DYRK1AKDM4EL3MBTL1SMN1; SMN2CCNT1 | |
| Hydrochloric Acid SCHEMBL21546060 | 0.80 | HTR2A (0.55) | DYRK1AKDM4ECCNT1PIM1CCNA2 | |
| SCHEMBL13036629 | 0.80 | DYRK1A (0.43) | DYRK1AKDM4ECCNT1PIM1CCNA2 | |
| SCHEMBL23585682 | 0.79 | DYRK1A (0.42) | DYRK1AKDM4ECCNT1PIM1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-26 | — | — | US | disclosed |
| US-7829555-B1 | Drug targeting | THE UNIVERSITY OF MANCHESTER (GB) | 2010-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | NR3C1, NR3C2, GRK3 | DYRK1A 3781/4885KDM4E 3498/4885L3MBTL1 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.