Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | PTPRB | P23467 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539988 | 0.84 | NPC1 (0.34) | NPC1RAB9AALDH1A1MEN1GAA | |
| SCHEMBL3707156 | 0.79 | PDCD1LG2 (0.36) | NPC1RAB9AALDH1A1MEN1GAA | |
| SCHEMBL22885900 | 0.75 | PDCD1LG2 (0.37) | ALDH1A1MEN1MAPTKMT2APDCD1LG2 | |
| SCHEMBL3699960 | 0.72 | CHRM1 (0.32) | CHRM1HRH1KCNH2 | |
| SCHEMBL3700231 | 0.70 | RAB9A (0.34) | RAB9ACHRM1HRH1KCNH2 | |
| SCHEMBL19773392 | 0.66 | SMN1; SMN2 (0.40) | NPC1RAB9AALDH1A1MEN1GAA | |
| SCHEMBL7665261 | 0.66 | SLC6A4 (0.39) | CD274KCNH2 | |
| SCHEMBL3717472 | 0.65 | PDCD1LG2 (0.36) | MEN1KMT2APDCD1LG2CD274 | |
| SCHEMBL3707159 | 0.64 | CHRM1 (0.31) | NPC1RAB9ACHRM1HRH1KCNH2 | |
| SCHEMBL3719113 | 0.64 | CD274 (0.38) | MEN1KMT2AHPGDPDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |