Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 11/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569970 | 0.89 | FBP1 (0.57) | FBP1PKMLMNANPC1RAB9A | |
| SCHEMBL957339 | 0.87 | FBP1 (0.60) | FBP1MAPT | |
| SCHEMBL959480 | 0.84 | FBP1 (0.56) | FBP1CSNK2A2CSNK2A1PKMLMNA | |
| SCHEMBL4566925 | 0.82 | FBP1 (0.51) | FBP1CSNK2A2CSNK2A1PKMLMNA | |
| SCHEMBL4570269 | 0.80 | FBP1 (0.60) | FBP1PKMLMNANPC1RAB9A | |
| SCHEMBL4570117 | 0.78 | FBP1 (0.56) | FBP1PKMLMNANPC1RAB9A | |
| SCHEMBL959968 | 0.77 | FBP1 (0.56) | FBP1PKMLMNANPC1RAB9A | |
| SCHEMBL4570506 | 0.77 | FBP1 (0.56) | FBP1PKMLMNANPC1RAB9A | |
| SCHEMBL4570017 | 0.75 | FBP1 (0.57) | FBP1PKMLMNANPC1RAB9A | |
| SCHEMBL957758 | 0.74 | FBP1 (0.54) | FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032548-A1 | THIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137962-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-06 | — | — | WO | disclosed |