Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.37 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | POLG | P54098 | 1/20 | 0.36 |
| ▸ | MGMT | P16455 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4572451 | 0.90 | POLB (0.42) | FGFR1POLBHPRT1POLA1POLG | |
| SCHEMBL4570533 | 0.88 | POLB (0.54) | FGFR1POLBHPRT1POLA1POLG | |
| SCHEMBL10044385 | 0.84 | FGFR1 (0.51) | FGFR1POLBCYP3A4CYP2D6HPRT1 | |
| SCHEMBL4572452 | 0.77 | POLB (0.58) | POLBHPRT1POLA1POLG | |
| SCHEMBL10072433 | 0.76 | POLB (0.43) | FGFR1POLBHPRT1POLA1POLG | |
| SCHEMBL17617659 | 0.76 | FGFR1 (0.50) | FGFR1POLBCYP3A4CYP2D6HPRT1 | |
| SCHEMBL17617658 | 0.74 | POLB (0.49) | FGFR1POLBHPRT1POLA1POLG | |
| SCHEMBL18470510 | 0.73 | FGFR1 (0.46) | FGFR1POLBCYP3A4CYP2D6HPRT1 | |
| SCHEMBL17617665 | 0.73 | FGFR1 (0.46) | FGFR1POLBCYP3A4CYP2D6HPRT1 | |
| SCHEMBL17625523 | 0.73 | POLB (0.51) | FGFR1POLBHPRT1POLA1POLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318700-B2 | Lung-targeted drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122818-A1 | LUNG-TARGETED DRUGS | DGKG, GK, PHOSPHO1 | FGFR1 822/4885POLB 4155/4885CYP3A4 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.