Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 15/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591348 | 0.92 | PIK3CB (0.71) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4573169 | 0.83 | PIK3CB (0.81) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL29434923 | 0.83 | PIK3CB (0.81) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL948460 | 0.78 | PIK3CB (0.85) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4306313 | 0.77 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| Hydrochloric Acid SCHEMBL3598484 | 0.76 | PIK3CB (0.66) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1431382 | 0.75 | PIK3CB (0.79) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1430841 | 0.74 | PIK3CB (0.78) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4844051 | 0.74 | PIK3CB (0.55) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4729576 | 0.74 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032036-A1 | 6-BENZIMIDAZ0LYL-2-M0RPH0LIN0-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032033-A1 | 4-BENZIMIDAZOLYL-2-MORPHOLINO-6-PIPERAZINYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |