Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 13/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573155 | 1.00 | SUV39H2 (0.47) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4589084 | 0.81 | SUV39H2 (0.49) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4589089 | 0.81 | SUV39H2 (0.49) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4590280 | 0.81 | SUV39H2 (0.49) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4590279 | 0.81 | SUV39H2 (0.49) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4590454 | 0.76 | NPC1 (0.40) | SUV39H2 | |
| SCHEMBL4573160 | 0.76 | SUV39H2 (0.47) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL8117347 | 0.76 | SUV39H2 (0.47) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4589911 | 0.75 | SUV39H2 (0.47) | SUV39H2NR1H2NR1H3GPR119MAP4K4 | |
| SCHEMBL4589914 | 0.75 | SUV39H2 (0.47) | SUV39H2NR1H2NR1H3GPR119MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |