Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 13/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589914 | 1.00 | SUV39H2 (0.47) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL20157181 | 0.84 | GHSR (0.49) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL20139336 | 0.84 | SUV39H2 (0.47) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL20139337 | 0.84 | SUV39H2 (0.47) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL4573983 | 0.83 | HRH3 (0.42) | HRH3 | |
| SCHEMBL13799383 | 0.81 | HRH3 (0.56) | GPR119HRH3 | |
| SCHEMBL15819221 | 0.79 | FAAH (0.56) | MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL20139199 | 0.79 | FAAH (0.56) | MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL20139589 | 0.79 | NR1H2 (0.59) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL20141060 | 0.79 | NR1H2 (0.55) | SUV39H2MAP4K4NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |