Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574386 | 0.87 | MAPT (0.64) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL5573222 | 0.85 | MAPT (0.76) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL12781689 | 0.84 | MAPT (0.67) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL12089783 | 0.82 | MAPT (0.65) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1459696 | 0.81 | MAPT (0.64) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6917550 | 0.81 | NAMPT (0.65) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13853617 | 0.80 | NAMPT (0.66) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2056118 | 0.79 | GPR119 (0.77) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL381360 | 0.79 | MAPT (0.68) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20423379 | 0.79 | KMT2A (0.60) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |