Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | NPR1 | P16066 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121636 | 0.83 | MAPK14 (0.43) | MAP4K4MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14131740 | 0.83 | MAPK14 (0.43) | MAP4K4MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4573310 | 0.83 | MAP4K4 (0.36) | TLR8TLR7TRPV3MAP4K4MAPK14 | |
| SCHEMBL4573181 | 0.82 | MERTK (0.37) | TLR8TLR7MAP4K4KCNH3MAPK14 | |
| SCHEMBL4573278 | 0.82 | MAP4K4 (0.42) | MAP4K4ALDH1A1HPGDCYP3A4TSHR | |
| SCHEMBL5112172 | 0.81 | MAPT (0.35) | MAP4K4ALDH1A1KDM4EGAKMAPK13 | |
| SCHEMBL5123850 | 0.80 | MAPT (0.43) | ALDH1A1HPGDKDM4EHSD17B10KCNH3 | |
| SCHEMBL5123059 | 0.77 | KCNH3 (0.46) | MAP4K4ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL4573442 | 0.77 | TP53 (0.47) | ALDH1A1KDM4ETSHRHSD17B10KCNH3 | |
| SCHEMBL5115353 | 0.77 | MAP4K4 (0.40) | MAP4K4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729089-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, DPYD, PNP | TLR8 2289/4885TLR7 964/4885IDH1 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.