Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.32 |
| ▸ | CKS1B | P61024 | 2/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14831080 | 0.75 | SCN9A (0.43) | PTGS1PTGS2HDAC4SCN9AMAP2K4 | |
| SCHEMBL14830870 | 0.73 | PSIP1 (0.53) | PTGS1PTGS2ALOX5APFEN1MRGPRX1 | |
| SCHEMBL3648948 | 0.71 | HDAC4 (0.40) | PTGS1PTGS2HDAC4MAP2K4ALOX5AP | |
| SCHEMBL22608 | 0.68 | — | — | |
| SCHEMBL4573131 | 0.68 | PTGS1 (0.37) | PTGS1PTGS2HDAC4SCN9AMAP2K4 | |
| SCHEMBL19991847 | 0.67 | SGK1 (0.34) | MAP2K4MAP2K7TDP1MRGPRX1 | |
| SCHEMBL4573296 | 0.67 | HDAC4 (0.43) | PTGS1PTGS2HDAC4MAP2K4MAP2K7 | |
| SCHEMBL1267271 | 0.66 | BRD4 (0.40) | PTGS1PTGS2HDAC4MAP2K4ALOX5AP | |
| SCHEMBL4600157 | 0.65 | — | — | |
| SCHEMBL1099375 | 0.65 | HDAC4 (0.47) | PTGS1PTGS2HDAC4MAP2K4MAP2K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | disclosed |