Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 7/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL682890 | 0.89 | PDE4B (0.46) | TLR9TLR8TLR7 | |
| SCHEMBL2084595 | 0.89 | PDE4B (0.46) | TLR9TLR8TLR7 | |
| SCHEMBL10290765 | 0.85 | ZAP70 (0.41) | TLR9TLR8TLR7DPP4HIF1A | |
| SCHEMBL310653 | 0.83 | ALDH1A1 (0.59) | ZAP70 | |
| SCHEMBL8270689 | 0.83 | TLR9 (0.55) | TLR9TLR8TLR7DPP4HIF1A | |
| SCHEMBL2243476 | 0.83 | TLR9 (0.55) | TLR9TLR8TLR7DPP4HIF1A | |
| Hydrochloric Acid SCHEMBL4572995 | 0.82 | TLR9 (0.54) | TLR9TLR8TLR7DPP4HIF1A | |
| SCHEMBL13163389 | 0.79 | CCR1 (0.44) | TLR9TLR8TLR7HIF1A | |
| SCHEMBL878044 | 0.78 | PDE4A (0.48) | — | |
| SCHEMBL683216 | 0.78 | PDE4A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |