Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116230 | 1.00 | MAP4K4 (0.60) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL31383652 | 0.88 | MAP4K4 (0.58) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL31383595 | 0.88 | MAP4K4 (0.58) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL29053096 | 0.86 | MAP4K4 (0.59) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL29053095 | 0.86 | MAP4K4 (0.59) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL4573088 | 0.85 | CHRM4 (0.58) | MAP4K4CHRM4GRM1HRH3ACACB | |
| SCHEMBL4584408 | 0.84 | MAP4K4 (0.52) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL8113244 | 0.84 | MAP4K4 (0.52) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL31383697 | 0.83 | MAP4K4 (0.56) | MAP4K4CHRM4HDAC1SUV39H2GPR119 | |
| SCHEMBL31383568 | 0.83 | MAP4K4 (0.56) | MAP4K4CHRM4HDAC1SUV39H2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |