Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113244 | 1.00 | MAP4K4 (0.52) | MAP4K4HDAC1SUV39H2GPR119HRH3 | |
| SCHEMBL38666762 | 0.85 | MAP4K4 (0.53) | MAP4K4HDAC1SUV39H2GPR119PIK3CD | |
| SCHEMBL38665917 | 0.85 | MAP4K4 (0.53) | MAP4K4HDAC1SUV39H2GPR119PIK3CD | |
| SCHEMBL4573559 | 0.85 | HRH3 (0.45) | HRH3CXCR3PIK3CDCHRM4GRM1 | |
| SCHEMBL8116230 | 0.84 | MAP4K4 (0.60) | MAP4K4HDAC1SUV39H2GPR119HRH3 | |
| SCHEMBL4573366 | 0.84 | MAP4K4 (0.60) | MAP4K4HDAC1SUV39H2GPR119HRH3 | |
| SCHEMBL4431585 | 0.81 | HRH3 (0.56) | MAP4K4SUV39H2GPR119HRH3CKS1B | |
| SCHEMBL28274242 | 0.81 | GPR119 (0.60) | MAP4K4HDAC1GPR119GRM1 | |
| SCHEMBL28274241 | 0.81 | GPR119 (0.60) | MAP4K4HDAC1GPR119GRM1 | |
| SCHEMBL26669805 | 0.80 | MAP4K4 (0.57) | MAP4K4HDAC1SUV39H2GPR119PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |