Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31658417 | 0.89 | MAP4K4 (0.52) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL30124551 | 0.86 | MAP4K4 (0.55) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL23867194 | 0.86 | MAP4K4 (0.55) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL30144181 | 0.86 | MAP4K4 (0.55) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL23867113 | 0.86 | MAP4K4 (0.55) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL23867109 | 0.86 | MAP4K4 (0.55) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL4573061 | 0.85 | ROCK2 (0.48) | ROCK2PRKG1HRH3GRM1FAAH | |
| SCHEMBL23867186 | 0.84 | MAP4K4 (0.56) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL23860098 | 0.84 | MAP4K4 (0.53) | MAP4K4GPR119HDAC1SUV39H2GRM1 | |
| SCHEMBL29182788 | 0.84 | MAP4K4 (0.53) | MAP4K4GPR119HDAC1SUV39H2GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |