Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 17/20 | 0.66 |
| ▸ | NR1H2 | P55055 | 17/20 | 0.66 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573487 | 1.00 | NR1H3 (0.66) | NR1H3NR1H2SUV39H2PDE4B | |
| SCHEMBL310527 | 0.87 | NR1H3 (0.58) | NR1H3NR1H2 | |
| SCHEMBL4573153 | 0.85 | SUV39H2 (0.56) | NR1H3NR1H2SUV39H2PDE4B | |
| SCHEMBL4573145 | 0.85 | SUV39H2 (0.56) | NR1H3NR1H2SUV39H2PDE4B | |
| SCHEMBL4573339 | 0.85 | NR1H2 (0.48) | NR1H3NR1H2 | |
| SCHEMBL13163392 | 0.83 | NR1H3 (0.54) | NR1H3NR1H2SUV39H2 | |
| SCHEMBL17745109 | 0.82 | NR1H3 (0.65) | NR1H3NR1H2 | |
| SCHEMBL17745107 | 0.82 | NR1H3 (0.65) | NR1H3NR1H2 | |
| SCHEMBL17385216 | 0.81 | NR1H3 (0.76) | NR1H3NR1H2 | |
| SCHEMBL17504931 | 0.81 | NR1H2 (0.76) | NR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |