Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506016 | 0.86 | SIRT6 (0.57) | NR1H2NR1H3 | |
| SCHEMBL3506011 | 0.86 | SIRT6 (0.57) | NR1H2NR1H3 | |
| SCHEMBL4573483 | 0.85 | NR1H3 (0.66) | NR1H2NR1H3 | |
| SCHEMBL4573487 | 0.85 | NR1H3 (0.66) | NR1H2NR1H3 | |
| SCHEMBL4585200 | 0.84 | CTSB (0.54) | HIF1ACTSBCTSSCTSK | |
| SCHEMBL27943428 | 0.78 | GFER (0.47) | NR1H2NR1H3 | |
| SCHEMBL4573031 | 0.75 | FAAH (0.46) | HIF1ACTSBCTSSCTSK | |
| SCHEMBL21433396 | 0.75 | NR1H2 (0.77) | NR1H2NR1H3 | |
| SCHEMBL21433393 | 0.75 | NR1H2 (0.77) | NR1H2NR1H3 | |
| SCHEMBL21433369 | 0.74 | NR1H2 (0.76) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |