Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73653 | 0.88 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CGAA | |
| SCHEMBL72180 | 0.87 | PDE4B (0.39) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8180654 | 0.81 | KDM4E (0.35) | PDE4BPDE4DPDE4APDE4CGAA | |
| SCHEMBL73108 | 0.81 | PDE5A (0.39) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL73968 | 0.81 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CGAA | |
| SCHEMBL73967 | 0.77 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CGAA | |
| SCHEMBL73650 | 0.74 | PDE4A (0.46) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL4574337 | 0.72 | PDE4D (0.38) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL4574938 | 0.71 | MEN1 (0.38) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL73465 | 0.70 | KDM4E (0.42) | PDE4BPDE4DPDE4APDE4CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008081282-A2 | PROCESS FOR THE SYNTHESIS OF N9-(3,5-DICHLORO-4-PYRIDYL)-6- DIFLUOROMETHOXYBENZO(4,5)FURO(3,2-C)PYRIDINE-9-CARBOXAMIDE AND SALTS THEREOF | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-07-10 | — | — | WO | disclosed |