Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NQO2 | P16083 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8786032 | 0.79 | TLR8 (0.56) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL60866 | 0.79 | KDM4E (0.56) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL8627406 | 0.77 | TLR8 (0.54) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL7045347 | 0.74 | TLR8 (1.00) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL27559755 | 0.74 | TLR8 (0.62) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9590284 | 0.73 | TLR8 (0.67) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL5117776 | 0.72 | TLR8 (0.65) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL180365 | 0.72 | TLR8 (0.65) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9589202 | 0.70 | TLR8 (0.62) | TLR8MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL12969936 | 0.70 | TLR8 (0.62) | TLR8MEN1KMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067390-A9 | METABOLITES OF 5-FLUORO-8-{4-[4-(6-METHOXYQUINOLIN-8-YL)PIPERAZIN-1-YL]PIPERIDIN-1-YL} QUINOLINE AND METHODS OF PREPARATION AND USES THEREOF | WYETH CORP (US) | 2009-05-22 | — | — | WO | disclosed |
| US-20080262228-A1 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof | WYETH (US) | 2008-10-23 | — | — | US | disclosed |
| WO-2008067390-A2 | METABOLITES OF 5-FLUORO-8-{4-[4-(6-METHOXYQUINOLIN-8-YL)PIPERAZIN-1-YL]PIPERIDIN-1-YL} QUINOLINE AND METHODS OF PREPARATION AND USES THEREOF | WYETH (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262228-A1 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof | UGT1A8, CYP2C8, NQO1 | TLR8 523/4885MEN1 1028/4885KMT2A 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.