Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27947668 | 0.82 | BCHE (0.56) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL5746436 | 0.77 | KDM4E (0.57) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL8322135 | 0.74 | PDE10A (0.49) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL29058206 | 0.74 | HRH3 (0.48) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL8322138 | 0.74 | PDE10A (0.64) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL8322172 | 0.74 | PDE10A (0.64) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL29604668 | 0.73 | HRH3 (0.71) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL5664122 | 0.73 | HRH3 (0.71) | HRH3HTR3EKDM4EHTR3BALDH1A1 | |
| SCHEMBL28803730 | 0.72 | KMT2A (0.53) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL31260651 | 0.72 | HRH3 (0.69) | HRH3HTR3EKDM4EHTR3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067390-A9 | METABOLITES OF 5-FLUORO-8-{4-[4-(6-METHOXYQUINOLIN-8-YL)PIPERAZIN-1-YL]PIPERIDIN-1-YL} QUINOLINE AND METHODS OF PREPARATION AND USES THEREOF | WYETH CORP (US) | 2009-05-22 | — | — | WO | disclosed |
| US-20080262228-A1 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof | WYETH (US) | 2008-10-23 | — | — | US | disclosed |
| WO-2008067390-A2 | METABOLITES OF 5-FLUORO-8-{4-[4-(6-METHOXYQUINOLIN-8-YL)PIPERAZIN-1-YL]PIPERIDIN-1-YL} QUINOLINE AND METHODS OF PREPARATION AND USES THEREOF | WYETH (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262228-A1 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof | UGT1A8, CYP2C8, NQO1 | HRH3 942/4885HTR3E 414/4885KDM4E 1201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.