Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 12/20 | 0.48 |
| ▸ | NPY1R | P25929 | 7/20 | 0.48 |
| ▸ | NPY2R | P49146 | 5/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.48 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 3/20 | 0.41 |
| ▸ | FNTB | P49356 | 3/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368601 | 1.00 | NPY4R (0.48) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL1119077 | 0.97 | NPY4R (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL5357516 | 0.97 | NPY4R (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL1711701 | 0.88 | GNPAT (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL29540393 | 0.88 | GNPAT (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL5966594 | 0.88 | GNPAT (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL5966602 | 0.88 | GNPAT (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL1711691 | 0.88 | GNPAT (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL7785244 | 0.88 | NPY4R (0.56) | NPY4RNPY1RNPY2RNPY5RKISS1R | |
| SCHEMBL7292029 | 0.88 | GNPAT (0.52) | NPY4RNPY1RNPY2RNPY5RKISS1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683396-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS | CSL Behring GmbH (DE) | 2014-01-15 | — | — | EP | claimed |
| WO-2012120124-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS | CSL BEHRING GMBH (DE) | 2012-09-13 | — | — | WO | claimed |
| WO-2008091692-A2 | METHODS OF DIAGNOSING, TREATING, AND PREVENTING INCREASED VASCULAR PERMEABILITY | JOSLIN DIABETES CENTER, INC. (US) | 2008-07-31 | — | — | WO | claimed |