Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677436 | 0.97 | TP53 (0.40) | TP53TSHRFFAR3LCKFYN | |
| SCHEMBL9730229 | 0.81 | FFAR3 (0.35) | TP53TSHRFFAR3LCKFYN | |
| SCHEMBL6053035 | 0.79 | — | — | |
| SCHEMBL9732271 | 0.75 | TP53 (0.36) | TP53FFAR3LCKFYN | |
| SCHEMBL8829936 | 0.75 | ALDH1A1 (0.32) | TP53TSHRFFAR3LCKFYN | |
| SCHEMBL2313654 | 0.73 | — | — | |
| SCHEMBL15496658 | 0.73 | — | — | |
| SCHEMBL27323652 | 0.73 | — | — | |
| SCHEMBL5047864 | 0.73 | TSHR (0.59) | TP53TSHRFFAR3LCKFYN | |
| SCHEMBL27675872 | 0.73 | TSHR (0.59) | TP53TSHRFFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778235-A4 | QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE AND AS PHOSPHODIESTERASE INHIBITORS | SHIRE HOLDINGS AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| EP-1778235-A2 | QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE AND AS PHOSPHODIESTERASE INHIBITORS | Shire Holdings AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006017823-A2 | QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE AND AS PHOSPHODIESTERASE INHIBITORS | SHIRE HOLDINGS AG (CH) | 2006-02-16 | — | — | WO | disclosed |
| EP-1082323-A2 | OXAZOLIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca UK Limited (GB) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999064417-A2 | OXAZOLIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 1999-12-16 | — | — | WO | disclosed |